FIRST DEFENSE® is a capsule containing antibodies which aid in the reduction of morbidity and mortality from neonatal calf scours caused by K99+ E. coli and bovine coronavirus. Maximal protection is achieved when administered in the first 12 hours after birth and used in conjunction with good colostrum feeding and calf nutrition programs. Neutralizing antibodies against bovine coronavirus as well as antibodies specific for E. coli K99+ pilus antigens present in FIRST DEFENSE® are prepared from hyperimmune bovine colostrum. A FIRST DEFENSE® capsule containing dried colostral antibodies dissolves readily upon reaching the calf’s stomach to provide passive protection against intestinal infection. Specific antibodies in FIRST DEFENSE® serve to block enterotoxigenic E. coli adherence and interfere with virus infection of intestinal epithelial cells, thereby reducing scours-related morbidity and mortality.